الملخص

Background: Obesity, a global public health concern, has been repeatedly linked to the development of different cancers in epidemiologic and basic  research studies, Prostate cancer  is the most frequently encountered solid tissue cancer in men. Gleason score  of  the prostate cancer is one of  the most important parameter, which provides the most important data about biological behavior of the cancer and affect on  the selection of the treatment and its outcomes. Therefore, accuracy of  Gleason score, based on  histopathological analysis of the biopsy material, has a critical importance Patients and Methods:  A cross-sectional study with retrospective  analytical elements, among prostate cancer patients who were  diagnosed based on histopathology of  prostate gland ,then classified accorrding to  G.S (gleasson score) and body mass index. Aim of this study: To evaluate the association between high  body mass index  and Gleason grade  of  prostate cancer. Results: The results of this study  showed that patients with high body mass index Significantly associated with high grade of prostate cancer, as ( 46.4%  and 62.2% of overweight and obese patients respectively had high Gleason score  above 7 while  12.5% of overweight and 8.1% of obese patients had low Gleason score  and the p Value was (0.002). Conclusion: This study found that high body mass index associated with increase high grade of  prostate cancer