الملخص

Objectives: The aims of the present study are; first, to find out the relative frequency of p53 over-expression in different types of breast cancer. Second, to correlate the p53 over-expression with different parameters, including the age and menopausal status of the patient, size, grade, stage, type of the tumor, and the status of axillary lymph nodes. Third, to compare our results with others Methods: The study was both pro and retrospective and included 60 cases of breast carcinoma. Data were obtained from archives of the pathology department, at Al-jumhuri Teaching Hospital and collected in a period spanning from August 2008 to January 2009. P53 over-expression was assessed immunohistochemically . Results: The patients ages ranged from 25 to 78 years (mean: 51.5 year); most of them were in the fourth decade (41.2%). There was a significant inverse relation between p53 over-expression and the age of the patients (p