Abstract
Background: Diffuse large B cell lymphoma (DLBCL) is an aggressive Non-Hodgkin lymphoma subtype.It is the most prevalant and responsible for thirty to forty percent of cases across various geographical locations with variable clinical presentations and underlying genetic diversity. B cell lymphoma 6 (BCL6 ) is a Proto-oncogenic transcriptional factor which is highly expressed in many lymphomas including diffuse large B-cell lymphoma.
Objectives: To assess BCL6 immunohistochemical expression in lymphomas of diffuse large B cell and its association with some clinical parameters (age, gender & presentation).
Material and Methods: During a period of ten months extending from November (2022) through August (2023), 61 diffuse large B cell lymphoma cases were included in this retro and prospective case series study, obtained from histopathological departments of governmental and private laboratories. Immunohistochemistry investigation using BCL6 was performed, and data of the positive BCL6 expression were evaluated.
Results: Out of 61 cases of lymphoma of diffuse large B cell, the mean age was 55 years, and the median was 61 years, with male predominance (55.7 %) vs (44.3 %) females. The nodal presentation is more frequent than extra nodal site (72.1% vs 27.9 %).41% of DLBCL cases was BCL6 positive (of which 56% were associated with age <60 years and 76% was nodal) with significant association between BCL6 expression and female gender (p value= 0.39).
Conclusion: BCL6 expression in diffuse large B cell lymphoma patients is more frequent in females and younger age (less than 60 years old).
