Abstract
Objectives: 1). To determine the prevalence of ESBLs producing Klebsiella species. 2). To examine their antibiogram profile. 3). To evaluate the association between ESBLs production and antibiotics resistance in Klebsiella isolates.
Materials and methods: This prospective study included 116 non repeated isolates of Klebsiella species 62 obtained from urine and 54 recovered from wounds. These bacterial isolates were re-identified and tested for antibiotic sensitivity against 19 selected antimicrobial agents. Also, these isolates were evaluated for extended spectrum beta lactamases (ESBLs) by double disk synergy test.
Results: Extended spectrum beta lactamases were found to be produced by 16.4% of the total studied Klebsiella isolates. Amikacin showed the lowest resistance rate (27.6%), while the highest one was detected against cephalothin, penicillin, cloxacillin and ampicillin (98.3%). The statistical analysis between ESBLs production and antibiotics resistance revealed a significant association only with ceftriaxone (p
