Plasma level of atrial natriuretic peptide during normal pregnancy and preeclampsia
Annals of the College of Medicine, Mosul,
Volume 31, Issue 1, Pages 1-5
Abstractobjective: To assess plasma atrial natriuretic peptide (ANP) level in pregnant andpreeclamptic women, and to evaluate the role of this hormone in the defense mechanismagainst body fluids and electrolytes disorders encountered under such physiologicaland pathophysiological conditions.Design: A case- series study.Setting: Al - Batool Teaching Hospital for Gynecology and Obstetrics, Mosul, during the period from December 2003 to September 2004.Participants: Twenty five women with normal pregnancy (group I ), 25 pregnant women withpreeclampsia (group ll ) and 25 healthy non pregnant women (control group) were included in this study.Methods: Plasma ANP, serum creatinine, urea, sodium and potassium were measured in allgroups. unpaired -t-test was used to examine the difference in the mean of the studiedparameters between different groups. Pearson correlation was used to assess the relationbetween different parameters within each group.Results: The mean of plasma ANP level was significantly higher in group I (p<0.05) and groupll (p<0.0001) than that in the control group. Furthermore, the plasma ANP level wassignificantly higher in group ll (p<0,0001) than that in group l. The mean of serum creatinineand serum urea were significantly higher in group ll than that in group l (p<0.005 and p<0.0001) and control group (p<0.0001 and p<0.0001).Conclusion: The results of this study indicate that plasma ANP level significantly increasesduring pregnancy especially among those who develop preeclampsia. Since ANP plays animportant role in the maintenance of body fluids and electrolytes homeostasis and bloodpressure regulation, estimation of plasma ANP level may be of value in better understandingand management of pathophysiological conditions that challenge the body homeostaticmechanisms during pregnancy.Key words: Atrial natriuretic peptide, preeclampsia.
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