Oxidative stress in epileptic patients on different antiepileptic monotherapy
Annals of the College of Medicine, Mosul,
2007, Volume 33, Issue 1, Pages 35-41
AbstractObjective: To assess, the oxidative stress (by assessing lipid peroxidation) and total antioxidant status, in epileptic patients on different antiepileptic monotherapy (carbamazepine (CBZ), valproic acid (VPA) or Phenobarbital (PhB)),in comparison with the control.Methods: This case-control study was conducted in the department of pharmacology- College of Medicine –University of Mosul from the 1st of June 2005 to the 15th of June 2006. A total of seventy four epileptic patients, on different antiepileptic monotherapy were included 38 on carbamazepine, 23 on valproic acid and 13 on phenobarbital, with 40 apparently healthy subjects as a control group for patients on carbamazepine or valproic acid and with 15 healthy children as a control group for patients on phenobarbital. For each patient and control subject, serum malondialdehyde (MDA) which reflects the lipid peroxidation, and total antioxidant status (TAS) were measured. Results: There was a significant increase in serum MAD level and a significant decrease in serum TAS level in epileptic patients on different antiepileptic monotherapy (CBZ, VPA and PhB). With the exception of patients on PhB, there was a poor correlation between MDA, TAS, the age of patients, the duration of illness and the duration of therapy.Conclusion: Epileptic patients on CBZ, VPA and PhB monotherapy had elevated lipid peroxidation as reflected by a significant increase in serum MDA and a decrease in serum TAS level, which might reflect a great impact on oxidative /antioxidant status.
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