Document Type : Research Paper

Authors

1 Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Iraq

2 Department of Pediatrics, Al-Hussein Specialized Children's Hospital, Al-Qadisiyah, Iraq

3 Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah

4 Department of Pharmacology and Therapeutics, College of Pharmacy, University of Al-Qadisiyah, Al-Qadisiyah , Iraq

Abstract

Background: Rotavirus infection is the most significant cause of severe dehydrating diarrhea, responsible for 5–10 million fatalities annually despite vaccinations. Acute rotavirus is the leading cause of vitamin A insufficiency by many mechanisms. 
Aims: To study the acute prognostic clinical effect of the addition of vitamin A on treating preschool-age patients with confirmed infection with acute rotavirus diarrhea.
Materials and methods: A randomized, double-blind study of 55 children from 6 to 72 months aged in Al-Hussein hospital for children with positive acute rotavirus infection from October 2022 to May 2023 in Al-Diwaniya city in Iraq, was classified into two groups with a vitamin A dose of 100000 IU for those age less than 12 months and 200000 IU for those older given in the first day of involvement, while the other group received a placebo.  
Results: Vitamin A significantly decreased stool consistency and frequency to significant levels and reduced the diarrheal severity of acute rotavirus and the period of hospitalization from 7.18 days to 5 days only.
Conclusion: Vitamin A intake in acute rotavirus infections significantly reduces the severity of diarrhea and hospitalization.

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