Document Type : Research Paper

Authors

1 Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah

2 ALKindy Teaching Hospital , Baghdad - Iraq

3 Department of Pharmacology and Therapeutics, College of pharmacy, University of Al-Qadisiyah

Abstract

Background: It is suggested that polymorphisms in the Vitamin D receptors gene (rs1544410 BsmI) may affect blood pressure in Iraqi patients with essential hypertension (EH). Essential hypertension accounts for 95% of all cases of hypertension. EH seems to be considerably affected by genetic factors and environmental factors.
Aim: To understand how vitamin D receptor gene polymorphism (VDR rs1544410 BsmI) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province.
Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension.  PCR-TETRA ARM technique was used, and blood samples were genotyped and examined for the polymorphisms BsmI (rs15444410) genes.
Results: The most frequent allele was C (95,53%) while the most frequent genotype was TC (57, 63%). There was no statistical difference between the actual and expected frequency distribution, according to Hardy-Weinberg equilibrium. The effect of VDR polymorphism rs1544410 on blood pressure indicates (the mean systolic blood pressure in homozygous TT, heterozygous TC, and homozygous CC carrier patients was 147, 151, and 147 respectively p=0.4. On the other hand, mean diastolic blood pressure in homozygous TT, heterozygous TC, and homozygous CC carrier patients was 87, 90, and 88 respectively p=0.3) there was no statistically significant effect on systolic and diastolic blood pressure.
Conclusion: Our study revealed that Vit D receptor gene polymorphism rs1544410 was not related to Vit D level, there was no statistically significant effect of rs1544410 on systolic and diastolic blood pressure.

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