susceptibility of yeast species to different concentration to fluconazole in leukemic and non- leukemic cancer patients
Annals of the College of Medicine, Mosul,
2020, Volume 42, Issue 1, Pages 42-49
Aim : Isolation and identification of yeast species in leukemic and non leukemic cancer patients and conduct the in vitro fluconazole susceptibility in different concentrations.
Patients and methods: This study included 100 oral swabs samples from cancer patients 50 of them were leukemic cancer patients group I, while group II patients were 50 non-leukemic cancer patients. Group I patients attending the hematology department in Ibn-Sina teaching hospital, and group II patients attending oncology and nuclear medicine teaching hospital in Mosul city. The clinical specimens were collected during period (June - December 2013).The patients included in this study were females only. Isolation and identification of yeast species depend on the classical methods. All the isolated yeast species were tested for their susceptibility to fluconazole concentrations (flu.10mcg, flu. 25mg, flu 50mcg) using standard disc agar diffusion method.
Results: C. albicans 28(52.8%), C. topicalis 1(1.9%), Cryptococcus laurentii 1(1.9%) all of them were higher in group I than group II, in addition C.parasilosis 1(1.9%) was higher in group II than group I, while C. glabrata was the same in group I 1(1.9%) and group II 1(1.9%). Fluconazole sensitivity test ranged from 40(38.1%), 34(32.4%), 31(29.5) to fluconazole discs potency 50mcg, 25mcg, 10mcg in both groups of cancer patients.
Conclusion: C. albicans, C. topicalis, Cryptococcus laurentii all of them were higher in group I than group II, in addition C.parasilosis was higher in group II than group I, while C. glabrata was the same in group 1 and group II. The sensitivity test to fluconazole were dose dependent with no significant difference between the three concentration to fluconazole
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