Main Subjects : Medical physiology
The Relationship between Cardiopulmonary Exercise testing (CPET), other Related Factors and Outcomes in Patients Undergoing Major Upper Gastrointestinal Surgery
Annals of the College of Medicine, Mosul,
Volume 41, Issue 1, Pages 1-10
Background: Assessment of patient’s fitness prior to major surgery is mandatory because co-morbidities predispose to postoperative complications; however the ability of pulmonary function tests to predict postoperative cardiopulmonary complications is still poorly defined.
Objective: to examine the role of preoperative measurements of cardiopulmonary exercise testing and other lung function tests in predicting postoperative outcomes in patients undergoing major upper gastrointestinal surgery (stomach, oesophagus, small intestine, gall bladder and pancreas surgery).
Patients and methods: A 193 patients who had major upper gastrointestinal surgery’ age, sex and smoking status were recorded and they underwent a range of tests including body mass index, flow-volume curve spirometry, blood gas analysis, transfer factor for carbon monoxide (TLCO) and CPET at the Pulmonary Function Laboratory of Glasgow Royal Infirmary between August 2008 and December 2011. Post-operative morbidity and mortality was analysed for all patients who underwent major surgery.
Results: Comparisons between patients that did or did not have post operative pulmonary complications showed significant differences in anaerobic threshold as % predicted maximum oxygen consumption during exercise (VO2; p<0.05), length of high dependency care stay (p<0.001), length of ward stay (p<0.01) and length of hospital stay (p<0.001). There were significant differences between those patients with and without operative anastomotic leak in body mass index (BMI; p<0.05), length of high dependency care stay (p<0.001), length of ward stay (6 vs.15, respectively; p<0.001), length of hospital stay (14 vs. 28, respectively; p<0.001) and duration between date of surgery and date of commencing postoperative chemotherapy (p≤0.01).
Conclusion: CPET and in particular anaerobic threshold % maximum predicted is useful in predicting the likelihood of the development of pulmonary complications in patients undergoing upper gastrointestinal surgery.
The Relationship between Pulmonary Function Testing Including Cardiopulmonary Exercise Testing (CPET) and Outcomes in Patients with Oesophagogastric Cancer Undergoing Neo-adjuvant Chemotherapy
Annals of the College of Medicine, Mosul,
Volume 41, Issue 1, Pages 43-51
Background: In the field of gastro-oesophageal cancer, the effect of chemotherapy treatment on patients’ cardiopulmonary fitness as well as on the incidence of post-operative cardiopulmonary complications remains controversial.
Objectives: To examine the effect of chemotherapy on cardiopulmonary fitness. Further, to examine the association between cardiopulmonary exercise testing and other measurements on outcomes in patients with gastro-oesophageal cancer undergoing neo-adjuvant chemotherapy. And to compare post chemotherapy cardiopulmonary exercise testing with surgical outcome.
Patients and methods: Forty-one patients with gastroesophageal cancer who underwent chemotherapy were referred to the Pulmonary Function Laboratory, Respiratory Medicine, Glasgow Royal Infirmary during the period August 2008 to December 2011. 35 of these patients underwent both pre- and post-chemotherapy pulmonary function testing and 31 of these 35 patients had their chemotherapy followed by surgery.
A further 6 patients underwent chemotherapy followed by pulmonary function testing and surgery but without pre-chemotherapy testing
Results: There were significant differences between the pre- and post-chemotherapy results in arterial PCO2 (p<0.01), t hemoglobin (p<0.001) and heart rate at anaerobic threshold as a % of maximum predicted heart rate (p<0.05). There were significant differences between those patients without post-operative complications and those with post-operative complications, in length of high dependency care stay (p<0.01), length of ward stay (p<0.05) and length of hospital stay (p<0.001)
Conclusion: the results of the present study show that there was no significant change in cardiopulmonary fitness in patients with gastro-oesophageal cancer who underwent chemotherapy apart from correctable side effect such as anaemia. In addition, CPET parameters, pulmonary function tests and other related factors did not predict an increase in the risk of post-operative complications. There was, however, a relationship between deprivation and an increased risk of postoperative complications.